Esobitt D40

Esobitt D40 is a combination of Esomeprazole and Domperidone, esomeprazole inhibits the H+/K+-ATPase enzyme(proton pump inhibitor), which is responsible for gastric acid secretion in the parietal cells of the stomach and irreversibly block the final step of acid secretion. It increases motility of Gl tract by inhibiting the action of dopamine and fastens gastric emptying. Domperidone stimulates Gl activity by acting as a competitive antagonist at dopamine D2 receptor.

Dyspepsia: Recurrent pain in abdomen with feeling full.

Peptic ulcer disease: Painful sores or ulcers in the lining of the stomach or first part of the small intestine, called the duodenum.

Gastro Esophageal Reflux Disease: It is a chronic symptom of mucosal damage caused by stomach acid coming up from the stomach into the esophagus

Zollinger-Ellison syndrome: gastrin-secreting tumor of the pancreas that stimulates the acid-secreting cells of the stomach to maximal activity. with consequent gastrointestinal mucosal ulcer

NSAIDS associated ulcer: Pain killer also cause ulcer.